Vectura has announced it is terminating development of its severe asthma therapy VR475, an inhaled formulation of the corticosteroid budesonide, after it failed in Phase 3 trials to demonstrate a significant impact on the condition.
Specifically, the therapy failed to show a reduction in the annualised rate of asthma exacerbations compared to placebo in severe asthma that is uncontrolled despite the use of high doses of inhaled steroids and a second controller medication. The drug was delivered via Vectura’s proprietary nebuliser.
