Roche has announced that it is to terminate two Phase 3 studies investigating the efficacy of its anti-beta-amyloid molecule crenezumab in the treatment of early sporadic Alzheimer’s disease (AD), after it became apparent that the drug was unlikely to meet its primary endpoint.
The decision was taken when a pre-planned interim analysis undertaken by an Independent Data Monitoring Committee determined that crenezumab would not generate an improvement from baseline in Clinical Dementia Rating-Sum of Boxes (CDR-SB) Score.
